Nation-state hackers pose a formidable threat to critical infrastructure, compromising national security, intellectual property, and public safety. This presentation will delve into the tactics, techniques, and procedures (TTPs) employed by nation-state actors, providing a core understanding essential for developing effective defense strategies. Through an in-depth analysis of three real-world case studies, we will expose the implications of nation-state attacks on laboratory, critical infrastructure, and industrial systems. We will examine how these attacks exploit human vulnerabilities, such as social engineering and insider threats, as well as system weaknesses, including misconfiguration and software vulnerabilities. Drawing from recent breaches in research laboratories and industrial manufacturing facilities, we will identify the root causes of these incidents, including human error, malicious insider actions, and inadequate security controls. This presentation aims to provide attendees with a comprehensive understanding of nation-state attack patterns, enabling them to strengthen their organization’s defenses against these sophisticated threats. Nathan Case is a cybersecurity engineer and strategist with over two decades of experience defending critical infrastructure, building secure cloud systems, and leading incident response at the highest levels. His career spans roles at Amazon Web Services, McKesson, and defense-focused startups, where he has architected platforms for healthcare, government, and national security missions. Known for his ability to bridge technical depth with real-world impact, Nathan has led global security teams, supported cyber operations across multiple countries, and advised both enterprise executives and government leaders on risk, resilience, and transformation.