In a cyber meta-reality filled with zero-day exploits, autonomous code, Worms modeled from Stuxnet, andthe coming onslaught of AI enabled malware, the need for actionable, virtually prescient threat intelligence isparamount. It is almost uniformly recognized that the current reactionary paradigm concerning cyber threats isseverely lacking. Cyber threat analysts desperately need a systematic approach to cyber threat characterization andhow cyber threats evolve within a greater construct defined here as the cyber microbiome. This paper will first definethe concept of the cyber microbiome and its place in what has become the cyber meta-reality. Cyber threats will thenbe examined in relation to this paradigm and recommendations will be made regarding how threat characterizationand genetic mutation can be examined in light of this new, techno-biological understanding.