This presentation introduces Micro-Segmentation and includes industry adoption statistics, strategies, and implementation examples. This presentation came from my personal experience implementing Micro-Segmentation in a fully virtualized hosted infrastructure environment for many large hospital systems. This talk will cover why we need segmentation, what the benefits are, how it evolved, and what it enables before explaining a flaw of Micro- Segmentation and how it is addressed using the recently defined term Nano-Segmentation. I also briefly touch on the famous Zero Trust Model and how Micro-Segmentation makes security more effective by following the principles of the Zero Trust Framework. Last, I will briefly cover how any organization can implement Micro and Nano-Segmentation using Tanium in a physical and/or virtual environment that scales up to millions of endpoints.