With the rapid development of sensing technologies, an increasing number of devices rely on sensors to measure environments or human beings and to control actuators. For instance, smartphones have a rich set of sensors, which range from accelerometers, microphones, to gyroscopes. Voice controllable systems rely on microphones to record voice command and autonomous vehicles depend on the barrier detection sensors to make driving decisions. Such a trend incurs new threats jeopardizing the system security and user privacy. In this talk, we show a collection of threats against the integrity of sensors and their impact on the systems level. For instance, we show that interference (EMI) can alter the measurement of analog sensors and thus affect the reliability of a close loop system. Finally, we discuss defense solutions that can improve the security of sensors.