The challenge of Industry 4.0 is to address requirements of Functional Safety and Security and to effectively manage risks related to digital technology. Organizations and their production facilities – especially those operating in support of critical infrastructure –have to be secured to enable continuous business and drive innovations. Key issues include how to monitor and assess components, systems and networks for technical vulnerabilities, as well as how to define and implement effective control measures. IEC 62443 is an internationally recognized standard for “IT security in Industrial Control Systems – Protection of Networks and Systems “, combining Functional Safety & Security to achieve necessary levels of protection. Joerg Krämer, Expert for Functional Safety and Nigel Stanley, Expert for Cyber Security will present and interpret the requirements of the IEC 62443 standard. They’ll demonstrate how system integrators, component vendors and system operators, (working at different risk levels), can implement a proportionate response to safety and security issues. In addition, they provide best practice advice on how to secure Industrial Control Systems against cyberattacks using technical and organizational measures, including conducting a targeted risk and threat analysis, implementing security by design, and comprehensive risk assessments that go beyond the requirements of the IEC 62443.