The continuous reports of data leakage arouse a lot of attention from banking, finance and government industries. Data protection to meet the PCI DSS compliance requirement is now a big challenge to all large enterprises in the field. It is imperative for security officer to deploy a truly robust and reliable solution to protect the enterprise data. This presentation will cover how organizations could be benefit by using application encryption hardware, endpoint protection with hard disk/file encryption software, and integration of data center centric database and file encryption products to obtain a comprehensive enterprise data protection solution.